Neutrinos from beta processes in a presupernova: probing the isotopic evolution of a massive star

We present a new calculation of the neutrino flux received at Earth from a massive star in the $\sim 24$ hours of evolution prior to its explosion as a supernova (presupernova). Using the stellar evolution code MESA, the neutrino emissivity in each flavor is calculated at many radial zones and time steps. In addition to thermal processes, neutrino production via beta processes is modeled in detail, using a network of 204 isotopes. We find that the total produced $\nu_{e}$ flux has a high energy spectrum tail, at $E \gtrsim 3 - 4$ MeV, which is mostly due to decay and electron capture on isotopes with $A = 50 - 60$. In a tentative window of observability of $E \gtrsim 0.5$ MeV and $t < 2$ hours pre-collapse, the contribution of beta processes to the $\nu_{e}$ flux is at the level of $\sim90\%$ . For a star at $D=1$ kpc distance, a 17 kt liquid scintillator detector would typically observe several tens of events from a presupernova, of which up to $\sim 30\%$ due to beta processes. These processes dominate the signal at a liquid argon detector, thus greatly enhancing its sensitivity to a presupernova.Comment: 14 pages, 5 figure

Operative Treatment of Cervical Myelopathy: Cervical Laminoplasty

Cervical spondylotic myelopathy (CSM) is a degenerative process which may result in clinical signs and symptoms which require surgical intervention. Many treatment options have been proposed with various degrees of technical difficulty and technique sensitive benefits. We review laminoplasty as a motion-sparing posterior decompressive method. Current literature supports the use of laminoplasty for indicated decompression. We also decribe our surgical technique for an open-door, or “hinged”, laminoplasty

AI-based Ecological Monitoring of Handwriting to Early Detect Cognitive Decline

The early detection of Mild Cognitive Impairment (MCI) is fundamental to initiate treatments for delaying the onset of dementia. Currently, the Mini Mental State Examination (MMSE) is one of the most common clinical scales used by geriatricians to assess cognitive function. A deviation of 1 to 3 points from the maximum score (30) is considered as sign of relevant cognitive decline. However, objective and affordable tools are needed to complement the screening process. The quantitative analysis of handwriting represents a suitable solution, as the gesture is significantly impaired in MCI subjects in terms of time, speed, fluency and applied pressure. This works presents the development and testing of classification models able to separate subjects at risk of cognitive decline (MMSE &lt;= 28) from controls (MMSE &gt; 28), starting from free-content handwriting data acquired with a smart ink pen, used on paper, from which 36 indicators were computed. Data were collected in 2 phases. The former involved 45 subjects and served for models training. In the latter, data were acquired from 23 subjects in a domestic longitudinal framework and were partially used for model refinement, but mainly for testing. Three different algorithms were tried (support vector machine, random forest and Catboost) The best test performances on the longitudinal data were obtained by a Catboost classifier, achieving accuracy 93.33%, precision 88.89%, recall 100% and f1 score 94.12%. The results support the use of computerized handwriting analysis as screening tool for cognitive decline detection

Neutrino Mixing and Cosmology

We review the consequences of neutrino mixing in the early universe. For both active-sterile mixing or mixing between three active neutrinos only, the consequences of oscillations depend crucially upon the size of the universe's lepton number (relic neutrino asymmetry.)Comment: 3 pages, talk at TAUP 200

Validity and usability of a smart ball&#8211;driven serious game to monitor grip strength in independent elderlies

Telemonitoring is one of the most expedient answers to the strong need for preventive care imposed by the rapidly aging society. We propose an innovative solution to the detection of early signs of frailty by presenting a serious game controlled by a smart sensorized soft plastic ball, designed to achieve continuous home-based monitoring of muscle weakness in older adults. Design, development, and testing of the smart ball and of the game interface devised to guide the monitoring procedure are presented. Reliability and concurrent validity of the system in measuring maximal grip strength against the clinical standard Jamar\uae were evaluated. Serious game usability and acceptance were investigated on 26 elderlies. Smart ball and Jamar measurements were well correlated (0.76 and 0.80 for dominant and non-dominant hands) and test\u2013retest reliability of pressure measurements was excellent (intraclass correlation coefficient &gt;0.94). The serious game was well accepted by the 96.1 percent of participants, who provided a strongly positive usability score (87.7/100). The smart ball\u2013driven serious game demonstrated excellent reliability and good validity in measuring grip strength. The proposed smart ball\u2013driven serious game can be used for home self-monitoring of grip strength in elderlies

High motor variability in DYT1 dystonia is associated with impaired visuomotor adaptation.

For the healthy motor control system, an essential regulatory role is maintaining the equilibrium between keeping unwanted motor variability in check whilst allowing informative elements of motor variability. Kinematic studies in children with generalised dystonia (due to mixed aetiologies) show that movements are characterised by increased motor variability. In this study, the mechanisms by which high motor variability may influence movement generation in dystonia were investigated. Reaching movements in the symptomatic arm of 10 patients with DYT1 dystonia and 12 age-matched controls were captured using a robotic manipulandum and features of motor variability were extracted. Given that task-relevant variability and sensorimotor adaptation are related in health, markers of variability were then examined for any co-variance with performance indicators during an error-based learning visuomotor adaptation task. First, we confirmed that motor variability on a trial-by-trial basis was selectively increased in the homogenous and prototypical dystonic disorder DYT1 dystonia. Second, high baseline variability predicted poor performance in the subsequent visuomotor adaptation task offering insight into the rules which appear to govern dystonic motor control. The potential mechanisms behind increased motor variability and its corresponding implications for the rehabilitation of patients with DYT1 dystonia are highlighted

Probing the neutrino mass hierarchy and the 13-mixing with supernovae

We consider in details the effects of the 13-mixing (sin^2 theta_{13}) and of the type of mass hierarchy/ordering (sign[ Delta m^2_{13}]) on neutrino signals from the gravitational collapses of stars. The observables (characteristics of the energy spectra of nu_e and antinu_e events) sensitive to sin^2 theta_{13} and sign[Delta m^2_{13}] have been calculated. They include the ratio of average energies of the spectra, r_E = /, the ratio of widths of the energy distributions, r_Gamma, the ratios of total numbers of nu_e and antinu_e events at low energies, S, and in the high energy tails, R_{tail}. We construct and analyze scatter plots which show the predictions for the observables for different intervals of sin^2 theta_{13} and signs of Delta m^2_{13}, taking into account uncertainties in the original neutrino spectra, the star density profile, etc.. Regions in the space of observables r_E, r_Gamma, S, R_{tail} exist in which certain mass hierarchy and intervals of sin^2 theta_{13} can be identified or discriminated. We elaborate on the method of the high energy tails in the spectra of events. The conditions are formulated for which sin^2 theta_{13} can be (i) measured, (ii) restricted from below, (iii) restricted from above. We comment on the possibility to determine sin^2 theta_{13} using the time dependence of the signals due to the propagation of the shock wave through the resonance layers of the star. We show that the appearance of the delayed Earth matter effect in one of the channels (nu_e or antinu_e) in combination with the undelayed effect in the other channel will allow to identify the shock wave appeareance and determine the mass hierarchy.Comment: LaTeX, 56 pages, 12 figures; a few clarifications added; typos corrected. Version to appear in JCA